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Ongoing diabetic foot ulcer problems?

Monash House Research Centre is conducting a clinical trial investigating a new treatment approach for people living with diabetic foot ulcers.
No cost to participate | Study-related care provided | Quick eligibility check
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About the study

Diabetic foot ulcers are a common and serious complication of diabetes. In some cases, ulcers can take months to heal or may not heal despite ongoing treatment.

This clinical trial is investigating an investigational therapy called CYWC628, designed to support tissue repair in chronic wounds when used alongside standard wound care.

Micrometer

Focus on hard-to-heal ulcers

The study is for people with diabetic foot ulcers that have not healed with standard care, helping researchers understand options for chronic wounds.

Lab

Investigational therapy plus standard care

CYWC628 is evaluated in addition to current best-practice wound care, so all participants receive standard treatment.

Hospital bed

Topical, non-surgical approach

The therapy is applied directly to the ulcer using a dressing and does not involve surgery or grafting.

Doctor coat

Structured monitoring and follow-up

Regular study visits allow close monitoring of wound healing and overall health.

User account

Contribution to future care

Participation helps medical teams gather important information that may inform future treatment approaches for people living with diabetic foot ulcers.

What is CYWC628?

CYWC628 is an investigational, cell-based therapy made from human dermal fibroblasts. Fibroblasts are cells that occur naturally in the body and are involved in tissue repair and wound healing.

In this study, CYWC628 is applied topically to the ulcer using a dressing as part of a structured treatment plan. The therapy is still being researched and is not approved for general use outside of clinical trials.

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Who may be eligible?

You may be eligible to participate in this study if you:

  • Are aged between 18 and 80
  • Have Type 1 or Type 2 diabetes
  • Have a diabetic foot ulcer that has not healed with standard care
  • Are able to attend regular study visits

For safety reasons, participants must not have a moderate or severe wound infection at the time of enrolment. Mild infection may be permitted at the study doctor’s discretion and can be treated before starting the study.

Final eligibility will be confirmed by the study team after screening and clinical assessment.

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What participation involves

If you are eligible and choose to join the study, your care will follow a structured plan with regular monitoring.

  • Study treatment assignment – you will be assigned to receive either standard wound care alone or standard wound care plus CYWC628, helping researchers compare outcomes.
  • Weekly visits for up to 12 weeks – you will attend regular study visits so the research team can review your ulcer, change dressings and monitor progress.
  • Ongoing health monitoring – your overall health and wound healing will be checked throughout the study.
  • Follow-up appointments – additional visits may occur after the main treatment period to assess longer-term outcomes.
  • Option to receive investigational therapy in some cases – if an ulcer does not heal with standard care alone, participants may later be eligible to receive CYWC628, depending on study criteria.
  • Reimbursement for time and participation – reasonable reimbursement is provided to recognise your time and involvement in the study.
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Why take part in clinical research?

Everyone has their own reasons for participating in clinical research. Common reasons include:

Supporting medical research that may improve future care for others with diabetic foot ulcers

Contributing to a better understanding of how chronic wounds heal over time

Accessing structured clinical monitoring of your ulcer and overall health within a hospital setting

Participation is voluntary. You are free to decide whether or not to take part, and you may withdraw from the study at any time without affecting your usual medical care.

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Safety and oversight

Your safety is the priority throughout this clinical trial.

  • Conducted at Monash House Research Centre – the study runs in a dedicated clinical research environment.
  • Ethics-approved research – the trial has received appropriate ethics approval and follows strict clinical research guidelines.
  • Qualified healthcare professionals – all participants are closely monitored by trained doctors and nurses.
  • Safety monitoring at every visit – your wound and general health are reviewed regularly, with clear processes if concerns arise.
  • Does not replace your usual care – taking part in this study does not replace the care you receive from your usual healthcare providers.
Register your interest

Register your interest

If you would like to learn more about this clinical trial and whether it may be suitable for you, please complete the form below.

Submitting an enquiry does not mean you are enrolled. A member of the research team will contact you to provide further information, discuss eligibility and answer any questions.


Disclaimer:  This study involves an investigational therapy. Participation may not provide direct benefit. All information provided is general and is not a substitute for professional medical advice. Monash House Research Centre can discuss individual eligibility and health considerations with you.